Research & Development
Publications
Regan CM, Foley AG, Prendergast A, Barry C, Scully D, Upton N, Medhurst AD, (2009) 'H3 receptor antagonism enhances NCAM PSA-mediated plasticity and improves memory consolidation in odor discrimination and delayed match-to-position paradigms'. Neuropsychopharmacology, 34 (12):2585-2600.
Foley AG, Hirst WD, Gallagher HC, Barry C, Hagan JJ, Upton N, Hunter AJ, Walsh FS, Regan CM (2008) 'The selective 5-HT(6) receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats'. Neuropharmacology, 54 (8):1166-1174.
Medhurst, AD, Briggs, MA, Bruton, G, Calver, AR, Chessell, I, Crook, B, Davis, JB, Davis, RP, Foley, AG, Heslop, T, Hirst, WD, Medhurst, SJ, Ociepka, S, Ray, A, Regan, CM, Sargent, B, Schogger, J, Stean, TO, Trail, BK, Upton, N, White, T, Orlek, B, Wilson, DM, (2007) 'Structurally novel histamine H-3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats'. Biochem Pharmacol, 73 :1182-1194.
Medhurst AD, Atkins AR, Beresford IJ, Brackenborough K, Michael Briggs MA, Calver AR, Cilia J, Cluderay JE, Crook B, Davis JB, Davis RK, Davis RP, Dawson LA, Foley AG, Gartlon J, Gonzalez MI, Heslop T, Hirst W, Jennings C, Jones DNC, Lacroix LP, Martyn A, Ociepka S, Ray A, Regan CM, Roberts JC, Schogger J, Southam E, Stean TO, Trail BK, Upton N, Wadsworth G, Wald JA, White T, Witherington J, Woolley ML, Worby A, Wilson DM (2007) 'GSK189254 - a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's Disease brain and improves cognitive performance in preclinical models'. Journal of Pharmacology and Experimental Therapeutics, 321:1032-1045.